Each Layout window has a printer associated with it. When you use the Page Setup dialog box (in the Output group), you are configuring your printer setting for your Layout window. For example, if you want to rotate your layout 90 degrees, to give it a landscape orientation, open the Page Setup dialog box and select Landscape.
The margins that you choose in the Page Setup dialog box display as a blank area around the edges of the Layout. The printable area of the Layout window begins where the margins end.
or Create 
, nothing in the margins will print. Layout frames within the margin area do not appear in the printout.Print settings made on the HOME tab by pointing to Print are applied to the Layout window and used for subsequent printouts.
Layout Paper Size
The layout paper size is tied to the printer settings. New windows are created with the default printer settings. Default printer and paper settings are made on the PRO tab, by clicking Options, and Printer.
You can override the default setting, by setting paper size, margins, and page orientation (portrait or landscape) for a Layout window. To do this on the HOME tab, in the Output group, click Page Setup to open the Page Setup dialog box.
Print OSBM
Off-Screen Bitmap (OSBM) automatically applies when printing a map frame that contains items or options that require OSBM to preserve their appearance in print. Using OSBM processes each print tile as a raster. This is an automatic setting that you cannot control when printing from a Layout window. Using OSBM applies when the Map has enhanced rendering turned on, and one or more visible layers with:
- Translucent vectors.
- Images (such as raster, grid, WMS, or tile server) with transparency, translucency, or image smoothing.
Printing to a layered PDF does not use the Print OSBM method.
Subdivide Printing
You can turn on subdivide printing as a preference (on the PRO tab, click Options, and Output Settings, on the Printing tab click Subdivide Printing). When subdivide printing is turned on and Print OSBM is not being used, then each map in a Layout window divides into smaller tiles while printing. This reduces the amount memory required to process the print job, especially when the map frame is large. When subdivide printing is off, then each map frame prints at once.
If your map contains translucent images (usually raster, grid, WMS, or TileServer images) and Enhanced Rendering is turned off, then it may not print as translucent. To make it print with translucency, on the PRO tab, click Options, and Styles. Check the Enable Enhanced Rendering check box.